Human MnSOD and Cancer Research

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Human Manganese Superoxide Dismutase

Human superoxide dismutase complex with Mn+2 ion (small purple) and K+ ion (large purple) (PDB code 2adq)

Drag the structure with the mouse to rotate

References

  1. 1.0 1.1 1.2 1.3 1.4 Azadmanesh J, Borgstahl GEO. A Review of the Catalytic Mechanism of Human Manganese Superoxide Dismutase. Antioxidants (Basel). 2018 Jan 30;7(2). pii: antiox7020025. doi:, 10.3390/antiox7020025. PMID:29385710 doi:http://dx.doi.org/10.3390/antiox7020025
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Borgstahl GE, Parge HE, Hickey MJ, Beyer WF Jr, Hallewell RA, Tainer JA. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Cell. 1992 Oct 2;71(1):107-18. PMID:1394426
  3. 3.0 3.1 3.2 Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol. 2003 Oct 15;552(Pt 2):335-44. doi: 10.1113/jphysiol.2003.049478. PMID:14561818 doi:http://dx.doi.org/10.1113/jphysiol.2003.049478
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Dhar SK, Batinic-Haberle I, St Clair DK. UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. J Biol Chem. 2019 Mar 11. pii: RA118.006595. doi: 10.1074/jbc.RA118.006595. PMID:30858178 doi:http://dx.doi.org/10.1074/jbc.RA118.006595
  5. 5.0 5.1 Church SL, Grant JW, Ridnour LA, Oberley LW, Swanson PE, Meltzer PS, Trent JM. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3113-7. PMID:8464931
  6. 6.0 6.1 6.2 6.3 Mapuskar KA, Anderson CM, Spitz DR, Batinic-Haberle I, Allen BG, E Oberley-Deegan R. Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues. Semin Radiat Oncol. 2019 Jan;29(1):72-80. doi: 10.1016/j.semradonc.2018.10.005. PMID:30573187 doi:http://dx.doi.org/10.1016/j.semradonc.2018.10.005
  7. 7.0 7.1 7.2 7.3 Torrens-Mas M, Hernandez-Lopez R, Oliver J, Roca P, Sastre-Serra J. Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer. J Cell Physiol. 2018 Aug;233(8):6067-6076. doi: 10.1002/jcp.26443. Epub 2018 Mar , 6. PMID:29323702 doi:http://dx.doi.org/10.1002/jcp.26443
  8. 8.0 8.1 Lu J, Zhang H, Chen X, Zou Y, Li J, Wang L, Wu M, Zang J, Yu Y, Zhuang W, Xia Q, Wang J. A Small Molecule Activator of SIRT3 Promotes Deacetylation and Activation of Manganese Superoxide Dismutase. Free Radic Biol Med. 2017 Jul 12. pii: S0891-5849(17)30684-6. doi:, 10.1016/j.freeradbiomed.2017.07.012. PMID:28711502 doi:http://dx.doi.org/10.1016/j.freeradbiomed.2017.07.012

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