Insulin lispro

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Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. See also [1]. Insulin lispro is a manufactured form of human insulin where the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule. This switch of amino acids mimics Insulin-like growth factor 1 which also has lysine and proline in that order.

Insulin Lispro Analog (6nwv).

Insulin Lispro, Human Insulin A chains (A, C, E, G, I, K) are colored in cyan and Human Insulin B chains (B, D, F, H, J, L) are colored in magenta.

Insulin Lispro Analog AB heterodimer.


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References

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Alexander Berchansky

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