Function
Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation[1]. ICAM contains 5 Ig-like domains.
- ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
- ICAM-2 mediates adhesive interactions important for antigen-specific immune response.
- ICAM-3 acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils[2].
- ICAM-5 has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.
Disease
ICAM mutation is involved in multiple sclerosis[3].
