Intercellular adhesion molecule

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Function

Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation[1]. ICAM contains 5 Ig-like domains.

  • ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
  • ICAM-2 mediates adhesive interactions important for antigen-specific immune response.
  • ICAM-3 acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils[2].
  • ICAM-5 has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.

Disease

ICAM mutation is involved in multiple sclerosis[3].


Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule

Updated on 04-July-2024

ICAM-1 (CD54)
ICAM-1 complexes
ICAM-2
ICAM-3
ICAM-5

References

  1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
  2. ↑ Kristóf E, Zahuczky G, Katona K, Doró Z, Nagy É, Fésüs L. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. Apoptosis. 2013 Oct;18(10):1235-51. PMID:23775590 doi:10.1007/s10495-013-0873-z
  3. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

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