Interleukin-1 receptor-associated kinase

From Proteopedia

Mouse IRAK4 death domain complex with Mn+2 ion , 2a9i Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Interleukin-1 receptor-associated kinase (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins[1]. Interleukin-1 receptor-associated kinase 1 (IRAK1) is a key link in the chain of events initiated by the binding of ligands to IL-R and Toll-like receptor [2]. Interleukin-1 receptor-associated kinase 2 (IRAK2) is involved in ER stress-induced cell death[3]. Interleukin-1 receptor-associated kinase 3 (IRAK3) is a critical modulator of inflammation in innate immunity[4]. Interleukin-1 receptor-associated kinase 4 (IRAK4) has scaffold function in myddosome formation [5]. Relevance IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection. Disease IRAK4 deficiency is a disorder which causes recurrent bacterial infections.

3D structures of interleukin-1 receptor-associated kinase

Updated on 07-July-2024

References

1. ↑ Cao Z, Henzel WJ, Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science. 1996 Feb 23;271(5252):1128-31. PMID:8599092
2. ↑ Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy. Oncotarget. 2018 Sep 7;9(70):33416-33439. PMID:30279971 doi:10.18632/oncotarget.26058
3. ↑ Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC. Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS One. 2013 May 28;8(5):e64256. PMID:23724040 doi:10.1371/journal.pone.0064256
4. ↑ Nguyen TH, Turek I, Meehan-Andrews T, Zacharias A, Irving H. Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis. PLoS One. 2020 Dec 31;15(12):e0244570. PMID:33382782 doi:10.1371/journal.pone.0244570
5. ↑ De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 Sep 28;293(39):15195-15207. PMID:30076215 doi:10.1074/jbc.RA118.003314