Kallikrein

spinqualitylabelsall models Structure of human kallikrein 4 complex with p-aminobenzamidine and Zn+2 ion (grey) (PDB code 2bdh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Kallikrein (KLK) or Enamel matrix serine proteinase 1 is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin. KLK1 releases the vasoactive peptide Lys-bradikinin from kininogen. KLK2 is prostate-specific. KLK4 cleaves extracellular matrix proteins. KLK5 and KLK7 regulate cell shedding. KLK6 regulates immune cells survival. KLK8 is involved inproteolytic cascade in the skin. plasma KLK cleaves Arg and Lys in kininogen to release bradykinin. Tissue KLK is expressed throughout the body. Disease Activation of the plasma KLK pathway may contribute to diabetic macular edema. KLK6 is implicated in carcinogenesis, Alzheimer and Parkinson diseases. KLK8 processes papilloma virus fascilitating their entry to host cells. . Structural highlights KLK being a serine protease contains the Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole. Water molecules shown as red spheres. 3D Structures of kallikrein Kallikrein 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman