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Pembrolizumab antibody against programmed cell death-1 receptor

Full-Length Crystal Structure of glycosylated Pembrolizumab complex with sulfate (PDB code 5dk3)

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  1. 1.0 1.1 Longoria TC, Tewari KS. Evaluation of the pharmacokinetics and metabolism of pembrolizumab in the treatment of melanoma. Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1247-53. doi:, 10.1080/17425255.2016.1216976. Epub 2016 Aug 16. PMID:27485741 doi:
  2. 2.0 2.1 2.2 2.3 Horita S, Nomura Y, Sato Y, Shimamura T, Iwata S, Nomura N. High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. Sci Rep. 2016 Oct 13;6:35297. doi: 10.1038/srep35297. PMID:27734966 doi:
  3. Rajakulendran T, Adam DN. Spotlight on pembrolizumab in the treatment of advanced melanoma. Drug Des Devel Ther. 2015 Jun 4;9:2883-6. doi: 10.2147/DDDT.S78036. eCollection, 2015. PMID:26082618 doi:
  4. Deeks ED. Pembrolizumab: A Review in Advanced Melanoma. Drugs. 2016 Mar;76(3):375-86. doi: 10.1007/s40265-016-0543-x. PMID:26846323 doi:

Melanie Kusakavitch also contributed equally to this project, but the computer program is not showing her name due to malfunction.

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