Function
Lactoferrin or lactotransferrin (LTF) is found in secretory fluids. LTF interacts with DNA, RNA, polysaccharides and heparin[1]. For detailed discussion of human lactoferrin see Human lactoferrin.
Relevance
LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity[2]. LTF can be used as a marker for inflammatory bowel disease[3].
Structural highlights
LTF is a bilobal protein with the . LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe[4]. The binding site is between the 2 domains of each lobe.
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The .
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The .