Leukotriene A4 Hydrolase

spinqualitylabelsall models Human leukotriene A4 Hydrolase complex with bestatin, acetate, imidazole, Yb+3 (green) and Zn+2 (grey) ions (PDB entry 1hs6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Leukotriene A4 Hydrolase (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism . LTA4H is a bifunctional Zn+2 enzyme. Relevance LTA4H inhibitors have potential in targeting chronic, autoimmune-driven inflammation . Disease Mutations in LTA4H are linked to susceptibility to asthma and to cardiovascular disease. Structural highlights LTA4H structure shows 3 domains: N-terminal, catalytic and C-terminal. The catalytic domain is made of 2 lobes: an α-helical one and an α/β one. The catalytic site is located between the 2 lobes and contains a Zn+2 ion. Water molecules shown as red spheres. 1st Yb coordination site. 2nd Yb coordination site.

3D Structures of Leukotriene A4 Hydrolase

Updated on 26-October-2025

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• LTA4H
  • 4rvb, 5fwq - hLTA4H – human
    
  • 1sqm, 1gw6, 1h19 - hLTA4H (mutant)
    
  • 1xpy, 2xpy, 2xpz – yLTA4H – yeast
    
• LTA4H + inhibitor
  • 3fh5, 3fh7, 3fh8, 3fhe, 3ful, 3fum, 3fun - hLTA4H+pyrrolidine inhibitor
  • 1hs6 - hLTA4H+bestatin
    
  • 3ftz, 3ftv, 3ftw, 3ftx, 3fui - hLTA4H+aniline derivative
    
  • 3fts, 3ftu - hLTA4H+resveratrol derivative
    
  • 3fty, 3fu0 - hLTA4H+pyridine derivative
    
  • 3fu3, 3fu5, 3fu6, 3fud - hLTA4H+thio derivative
    
  • 3fue, 3fuf, 3fuh - hLTA4H+bestatin+indole derivative
    
  • 3fuj, 3fuk - hLTA4H+indole derivative
    
  • 3b7r, 3cho, 3chp, 3chq, 3chr, 3chs, 2r59, 3u9w, 4r7l, 4rsy, 5aen, 5bpp, 6enc, 6end, 7auz, 7av0, 7av1, 7av2, 8ava, 8awh, 8twx - hLTA4H+inhibitor
    
  • 3b7u - hLTA4H+kelatorphan
    
  • 2vj8 - hLTA4H+hydroxamic acid
    
  • 4dpr – hLTA4H + captopril
    
  • 4ms6, 7kze, 7llq - hLTA4H +tripeptide analog
    
  • 4l2l - hLTA4H + thiazol derivative
    
  • 4mkt - hLTA4H +tripeptide analog + thiazol derivative
    
  • 3b7s, 3b7t, 6enb - hLTA4H (mutant)+tripeptide
    
  • 6o5h – hLTA4H + modifier
    
  • 4gaa - LTA4H+bestatin – frog
    
  • 2xq0 – yLTA4H+bestatin
    

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