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Ligand-Gated Ion Channels (LGIC) open or close when binding a ligand like a neurotransmitter[1].
See Structural evidence for mono- and di-carboxylates binding at pharmacologically relevant extracellular sites of a pentameric ligand gated ion channel [2]
References
- ↑ Keramidas A, Moorhouse AJ, Schofield PR, Barry PH. Ligand-gated ion channels: mechanisms underlying ion selectivity. Prog Biophys Mol Biol. 2004 Oct;86(2):161-204. PMID:15288758 doi:http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002
- ↑ Fourati Z, Sauguet L, Delarue M. Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol. 2020 Jul 1;76(Pt 7):668-675. PMID:32627739 doi:10.1107/S205979832000772X
