Function
Malate synthase (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. MS G is formed during growth on glycolate[1] and MS A which metabolizes glyoxylate formed in the dissimilation of acetate.
See also: Glyoxylate cycle
Structural highlights
. The ternary complex contains malate, acetyl-CoA and Mg+2 ion[2].
. Water molecules are shown as red spheres.
.
3d structures of malate synthase
Malate synthase 3D structures
