Methanol dehydrogenase

From Proteopedia

Methanol dehydrogenase large subunit (cyan and deeppink) and small subunit (green and yellow) complex with cofactor PQQ and Ca+2 ion (green), 2ad6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Methanol dehydrogenase or sulfoacetaldehyde reductase (MDH) is a quinoprotein which catalyzes the conversion of methanol and NAD+ or NADP+ to formaldeyde and NADH or NADPH and H+. MDH is a pyrroloquinoline quinone (PQQ)-dependent enzyme. MDH requires a divalent cation like Ca+2 for catalytic activity[1]. Structural highlights are bound in a [2]. Water molecules are shown as red spheres.

3D structures of methanol dehydrogenase

Updated on 02-November-2021

4aah, 1g72, 2ad6, 2ad7, 2ad8 – MmMDH α+β + Ca + PQQ – Methylophilus methylotrophus
1h4i, 1w6s - MeMDH α+β + Ca + PQQ – Methylobacterium extorquens
1h4j - MeMDH α (mutant) +β + Ca + PQQ
1lrw - MDH α+β + Ca + PQQ – Paracoccus denitrificans
2d0v - MDH α+β + Ca + PQQ – Hyphomicrobium denitrificans
4mae - MfMDH + Ce + PQQ – Methylacidiphilum fumariolicum
6fkw - MfMDH + Eu + PQQ
7ced - McMDH α+β – Methylococcus capsulatus
4tqo, 7cdl, 7ce5, 7ce9, 7cfx - McMDH α+β + Ca + PQQ
5xm3 - MDH α+β + Mg + PQQ – Methylophaga aminisulfidivorans
6dam - MDH + La + PQQ – Methyomicrobium byryatense
6jko - BkMDH + Zn – Bifidobacterium kashiwanohense
6jkp - BkMDH + Zn + NAD
6onp, 6onq - MexMDH – Methylorubrum extorquens
6oc5 - MexMDH + La
6oc6 - MexMDH + La + PQQ
7o6z - MDH α + Nd + PQQ – Methylacidimicrobium

References

1. ↑ Anthony C, Williams P. The structure and mechanism of methanol dehydrogenase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):18-23. PMID:12686102
2. ↑ Li J, Gan JH, Mathews FS, Xia ZX. The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase. Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. Epub 2011 Feb 26. PMID:21356200 doi:10.1016/j.bbrc.2011.02.107