Methionine gamma-lyase

From Proteopedia

Methionine γ-lyase complex with PLP and sulfate (PDB code 1pg8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Methionine γ-lyase (MGL) degrades sulfur-containing amino acids to α-keto acids, ammonia and thiols. It catalyzes the interconversion of L-methionine and water to methanethiol, ammonia and 2-oxobutanoate. MGL uses pyridoxal phosphate (PLP) as cofactor[1]. Structural highlights MGL active site contains the cofactor PLP[2]. 3D Structures of methionine γ-lyase Methionine gamma-lyase 3D structures

References

1. ↑ Goyer A, Collakova E, Shachar-Hill Y, Hanson AD. Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. Plant Cell Physiol. 2007 Feb;48(2):232-42. Epub 2006 Dec 13. PMID:17169919 doi:http://dx.doi.org/10.1093/pcp/pcl055
2. ↑ Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV. Structure of Citrobacter freundii L-methionine gamma-lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:16511092 doi:10.1107/S1744309105015447