Methyl CpG binding protein

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Structure of mouse MBD4 glycosylate domain complex with DNA containing mismatch, ethylene glycol and Ni+2 ion (green) (PDB code 4evv).

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  1. Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:
  2. Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
  3. Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res. 2012 Jun 27. PMID:22740654 doi:10.1093/nar/gks628

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Michal Harel, Alexander Berchansky

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