Mg-8 may contribute to the binding to factors VIIa and X

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Image:GlaIonsP5.jpg

Model of factor IXa[1]. The epidermal growth factor (green) and serine protease (yellow) domains of factor IXa (42) are shown connected to the IXGD1–46 structure (white), using factor VIIa structure (17) as a reference model. The bound Mg2+ and Ca2+ ions are drawn as orange and blue spheres, respectively. D-Phe-Pro-Arg-chloromethylketone, which is bound to the active site, is shown as a red stick model. The phospholipid membrane surface is shown by a yellow line. Hydrophobic residues (yellow), basic residues (purple) and Mg2+ ion (Mg-1) of GD1–46 are possible candidates for membrane binding.

Additional Resources

For additional information, see: Hemophilia


References

  1. ↑ Shikamoto Y, Morita T, Fujimoto Z, Mizuno H. Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. J Biol Chem. 2003 Jun 27;278(26):24090-4. Epub 2003 Apr 14. PMID:12695512 doi:10.1074/jbc.M300650200

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