Function
Monomethyamine methyltransferase (MtmB) initiates methanogenesis from mono-, di- and trimethylamines. The genes contain a UAG codon which is decoded by a special tRNA as Pyrrolysine. The pyrrolysine activates and optimally orients methylamine for methyl transfer[1]. Pyrrolysine is considered as the 22st amino acid.
Structural highlights
Pyrrolysine, encoded by the UAG codon is observed in the active site of MtmB[2].
3D structures of monomethyamine methyltransferase
Monomethyamine methyltransferase 3D structures
