Mycobacterium Tuberculosis Transpeptidase Domain

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Mtb Transpeptidase Domain in Complex with Penicillin

M. tuberculosis penicillin-binding protein transpeptidase domain complex with penicillin V, HEPES and PEG (PDB code 5cxw).

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References

Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J., & Anderson, W. F. (2016). Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The FEBS journal, 283(12), 2206-2218.

Maria-Magdalena Patru, Martin S. Pavelka, Jr. A Role for the Class A Penicillin-Binding Protein PonA2 in the Survival of Mycobacterium smegmatis under Conditions of Nonreplication, J Bacteriol. 2010 Jun; 192(12): 3043–3054. Published online 2010 Apr 16. doi: 10.1128/JB.00025-10

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