Myosin light chain kinase

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Two monomers of human myosin light chain kinase residues 40-388 complex with pyrimidine derivative, pentaethylene glycol, ethanediol and sulfate ion (PDB entry 2x4f)

3D structures of MLCK

Updated on 05-November-2019

2x4f – hMLCK residues 40-388 - human
6c6m - hMLCK 3rd Ig-like domain residues 405-507
2yr3 - hMLCK 4th Ig-like domain residues 510-601 – NMR
2cqv – hMLCK 8th Ig-like domain residues 1238-1338 – NMR


  1. Stull JT, Tansey MG, Tang DC, Word RA, Kamm KE. Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization. Mol Cell Biochem. 1993 Nov;127-128:229-37. PMID:7935354
  2. Flores C, Ma SF, Maresso K, Ober C, Garcia JG. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Genet Epidemiol. 2007 May;31(4):296-305. PMID:17266121 doi:
  3. Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest. 2005 Oct;115(10):2702-15. Epub 2005 Sep 22. PMID:16184195 doi:

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