NADPH Cytochrome P450 Oxidoreductase

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NADPH cytochrome P450 oxidoreductase complex with flavin mononucleotide, FAD and NADP, (PDB Code 3es9)

3D structures of NADPH-cytochrome P450 oxidoreductase

NADPH-Cytochrome P450 Reductase

Additional Resources

For additional information, see: Cancer


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  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26. PMID:19171935 doi:10.1074/jbc.M807868200
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  4. 4.0 4.1 Smith GC, Tew DG, Wolf CR. Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8710-4. PMID:8078947
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  7. Ram PA, Waxman DJ. Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. J Biol Chem. 1992 Feb 15;267(5):3294-301. PMID:1737785
  8. 8.0 8.1 8.2 8.3 Tomkova M, Marohnic CC, Baxova A, Martasek P. [Antley-Bixler syndrome or POR deficiency?] Cas Lek Cesk. 2008;147(5):261-5. PMID:18630181
  9. 9.0 9.1 9.2 9.3 Nadler SG, Strobel HW. Identification and characterization of an NADPH-cytochrome P450 reductase derived peptide involved in binding to cytochrome P450. Arch Biochem Biophys. 1991 Nov 1;290(2):277-84. PMID:1929397
  10. 10.0 10.1 10.2 10.3 Tamburini PP, Schenkman JB. Differences in the mechanism of functional interaction between NADPH-cytochrome P-450 reductase and its redox partners. Mol Pharmacol. 1986 Aug;30(2):178-85. PMID:3016501
  11. Hasemann CA, Kurumbail RG, Boddupalli SS, Peterson JA, Deisenhofer J. Structure and function of cytochromes P450: a comparative analysis of three crystal structures. Structure. 1995 Jan 15;3(1):41-62. PMID:7743131
  12. 12.0 12.1 Canessa M, Laski C, Falkner B. Red blood cell Na+ transport as a predictor of blood pressure response to Na+ load in young blacks and whites. Hypertension. 1990 Nov;16(5):508-14. PMID:2228151
  13. 13.0 13.1 13.2 Shen AL, O'Leary KA, Kasper CB. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. J Biol Chem. 2002 Feb 22;277(8):6536-41. Epub 2001 Dec 12. PMID:11742006 doi:10.1074/jbc.M111408200
  14. 14.0 14.1 14.2 Miller WL, Huang N, Pandey AV, Fluck CE, Agrawal V. P450 oxidoreductase deficiency: a new disorder of steroidogenesis. Ann N Y Acad Sci. 2005 Dec;1061:100-8. PMID:16467261 doi:1061/1/100

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