Function
NADPH dehydrogenase or old yellow enzyme or NADH:flavin oxidoreductase/NADH oxidase or prostaglandin F2A synthase or chromate reductase (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor[1]. See NAD(P)H. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN.
- NADPH dehydrogenase quinone 1 (NQO1) reduces quinones to hydroquinones.
- NADPH dehydrogenase quinone 2 (NQO2) catayzes electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain[2].
Structural highlights
[3]. Water molecules are shown as red spheres.