Nerve growth factor

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Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code 1www)

3D structures of nerve growth factor

Updated on 09-November-2020

4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra


  1. Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:
  2. Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:
  3. Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705

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