Nerve growth factor

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Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code 1www)

3D structures of nerve growth factor

Updated on 09-November-2020

4edk, 4edw, 5jz7 - hβ-NGF + antibody - human
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra

References

  1. Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
  2. Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
  3. Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705

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