Nerve growth factor

From Proteopedia

Function Nerve growth factor (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions[1]. NGF interacts with 2 transmembrane receptors - TrkA and p75. Relevance Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker[2]. Structural highlights The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the receptor D-5 domain Ig-like structure flanking the NGF homodimer. Various side chains form the interactions between NGF and its receptor with a totally buried NGF Arg residue forming the strongest one[3]. Water molecules are shown as red spheres.

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3D structures of nerve growth factor

Updated on 17-November-2021

6yw8 - hβ-NGF – human - NMR
4edk, 4edw, 5jz7 - hβ-NGF + antibody
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra

References

1. ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
2. ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
3. ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705