Neurophysin

From Proteopedia

Function Neurophysins are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland[1]. Neurophysin-1 transports oxytocin. Neurophysin-2 transports vasopressin. Oxytocin is used to start labor and increase its speed. Vasopressin functions to retain water in the body and to constrict blood vessels. Disease Mutations in neurophysin-2 are associated with familial diabetes[2]. Structural highlights Neurophysin-2/oxytocin interactions.

spinqualitylabelsall models Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code 1npo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of neurophysin

Updated on 23-July-2019

Neurophysin-1

2lbh, 2lbn – bNP1 – bovine - NMR

1l5c, 1l5d – bNP1 (mutant) - NMR

2hnw – bNP1 (mutant)

2hnu, 2hnv – bNP1 (mutant) + dipeptide

Neurophysin-2

1jk6 – bNP2

1npo – bNP2 + oxytocin

1jk4 – bNP2 + Lys vasopressin

2bn2 – bNP2 + dipeptide

References

1. ↑ Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID:3147712
2. ↑ Nagasaki H, Ito M, Yuasa H, Saito H, Fukase M, Hamada K, Ishikawa E, Katakami H, Oiso Y. Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. J Clin Endocrinol Metab. 1995 Apr;80(4):1352-6. PMID:7714110 doi:http://dx.doi.org/10.1210/jcem.80.4.7714110