Neuropilin

Function

Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins^[1]. There are 2 classes of NRP – NRP-1 and NRP-2.

• NRP-1 has high affinity for semaphorin-3A.
  
• NRP-2 has high affinity for semaphorin-3F.

Relevance

NRP are highly expressed in human neoplasms^[2].

Structural highlights

NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region.

• Ca coordination site. Water molecule are shown as red sphere.