Function
Neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin-2 is involved in innate immunity by sequestering bacterial iron and thus preventing bacterial growth[1]. Lipocalin-1 (Lcn1) or Tear lipocalin is a major protein in tears which binds diverse set of lipophilic molecules [2].
Relevance
NGAL is secreted in high levels into the blood following acute kidney injury and thus can be used as a biomarker for it[3]. Lcn1 functions in tears includes their viscosity and it serves as biomarker for dry eyes.
Structural highlights
like carboxymycobactin or enterobactin[4]. Water molecules are shown as red spheres.