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Human neutrotrophin-4 (green) complex with TRKB (pink) and sulfate (PDB code 1hcf)

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3D structures of neutrotrophin

Updated on 31-March-2020

  • Neutrotrophin-3

1b8k, 1nt3 – hNT3 - human
1bnd – hNT3 + brain derived neutrotrophic factor
3buk – hNT3 + P75NTR

  • Neutrotrophin-4

1b98 – hNT4

1b8m – hNT4 + brain derived neutrotrophic factor
1hcf – hNT4 + TRK-B


  1. Ginty DD, Segal RA. Retrograde neurotrophin signaling: Trk-ing along the axon. Curr Opin Neurobiol. 2002 Jun;12(3):268-74. doi: 10.1016/s0959-4388(02)00326-4. PMID:12049932 doi:
  2. Elmariah SB, Hughes EG, Oh EJ, Balice-Gordon RJ. Neurotrophin signaling among neurons and glia during formation of tripartite synapses. Neuron Glia Biol. 2004 Nov;1(4):1-11. doi: 10.1017/S1740925X05000189. PMID:16528404 doi:
  3. Pramanik S, Sulistio YA, Heese K. Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy. Mol Neurobiol. 2017 Nov;54(9):7401-7459. doi: 10.1007/s12035-016-0214-7. Epub, 2016 Nov 5. PMID:27815842 doi:

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