Nucleoside triphosphatase

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NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB code 4a5a).

3D structures of nucleoside triphosphatase

Updated on 19-May-2020

References

  1. Krug U, Totzauer R, Zebisch M, Strater N. The ATP/ADP Substrate Specificity Switch between Toxoplasma gondii NTPDase1 and NTPDase3 is Caused by an Altered Mode of Binding of the Substrate Base. Chembiochem. 2013 Oct 2. doi: 10.1002/cbic.201300441. PMID:24115522 doi:http://dx.doi.org/10.1002/cbic.201300441
  2. Roszek K, Czarnecka J. Is Ecto-nucleoside Triphosphate Diphosphohydrolase (NTPDase)-based Therapy of Central Nervous System Disorders Possible? Mini Rev Med Chem. 2015;15(1):5-20. doi: 10.2174/1389557515666150219114416. PMID:25694082 doi:http://dx.doi.org/10.2174/1389557515666150219114416
  3. Krug U, Zebisch M, Krauss M, Strater N. Structural insight into the activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction. J Biol Chem. 2011 Nov 30. PMID:22130673 doi:10.1074/jbc.M111.294348

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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