Function
O-GlcNac transferase or O-glycosyltransferase (OGT) catalyzes the addition of N-acetylglucosamine (GlcNAc) to serine or threonine residues by O-glycosylation[1]. OGT contains 2 subunits: a 110 kDa and a 78kDa. The 110 kDa subunit contains a superhelical domain with 13 tetratricopeptide (TPR) repeats. The TPR motif consists of 34 amino acids and mediates protein-protein interactions.
- MurG:UDP-GlcNac is an OGT which forms glycosidic linkage between N-acetyl muramyl pentapeptide and N-acetyl glycosamine in the synthesis of bacterial cell wall[2].
For details see Human O-GlcNAc transferase.
Structural highlights
[3]. Water molecule is shown as red sphere.
3D structures of O-GlcNAc transferase
O-GlcNAc transferase 3D structures