Oxaloacetate/aspartate: lysine, asparagine, methionine, threonine, and isoleucine

The oxaloacetate/aspartate family of amino acids is composed of lysine, asparagine, methionine, threonine, and isoleucine. Aspartate can be converted into lysine, asparagine, methionine and threonine. Threonine also gives rise to isoleucine. The associated enzymes are subject to regulation via feedback inhibition and/or repression at the genetic level. As is typical in highly branched metabolic pathways, additional regulation at each branch point of the pathway.

The biosynthesis of aspartate frequently involves the transamination of Citric Acid Cycle intermediate oxaloacetate.

See also:

• Amino Acid Synthesis