Function
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis[1].
Three types of PanK are known.
- PanK I found in bacteria
- PanK II found mostly in eukaryotes
- PanK III found in bacteria and known as CoaX.
Disease
Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration[2].
Structural highlights
[3].
3D structures of pantothenate kinase
Pantothenate kinase 3D structures