Peptidyl-tRNA hydrolase

From Proteopedia

Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry 3vjr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Peptidyl-tRNA hydrolase (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA[1]. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. Structural highlights PTH dimer interacts with tRNA at the latter's ; the and the TΨC site (Ψ is pseudouridine) which is the [2].

3D Structures of peptidyl-tRNA hydrolase

Updated on 22-August-2023

References

1. ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
2. ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790