Phosphoenolpyruvate carboxykinase

Function

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO₂. PEPCK is part of the gluconeogenesis pathway^[1]. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.

See also: Gluconeogenesis.

Structural highlights

E. coli GTP-driven PEPCK is located in a pocket at the enzyme surface^[2]. Water molecules are shown as red spheres.

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3D Structures of PEPCK

Phosphoenolpyruvate carboxykinase 3D structures