Function
Phospholipase D (PLD) hydrolyzes phosphatidylcholine (PC) into phosphatidic acid and choline[1]. PLD is found in organisms ranging from virus to mammals.
Relevance
Dysregulation of lipid pathways is involved in many neurodegenerative disorders like Alzheimer disease. Brains of Alzheimer disease patients show decreased levels of PC and increased activity of PLD[2].
Structural highlights
The [3]. Water molecule are shown as red sphere.
3D structures of phospholipase D
Phospholipase D 3D structures