Phospholipase D

From Proteopedia

Contents 1 Function 2 Relevance 3 Structural highlights 4 3D structures of phospholipase D Function Phospholipase D (PLD) hydrolyzes phosphatidylcholine (PC) into phosphatidic acid and choline[1]. PLD is found in organisms ranging from virus to mammals. Relevance Dysregulation of lipid pathways is involved in many neurodegenerative disorders like Alzheimer disease. Brains of Alzheimer disease patients show decreased levels of PC and increased activity of PLD[2]. Structural highlights The active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine[3]. Water molecule are shown as red sphere. 3D structures of phospholipase D Phospholipase D 3D structures

spinqualitylabelsall models Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
2. ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
3. ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003