Poliovirus receptor-related protein

From Proteopedia

Function Poliovirus receptor-related protein (PVRP) or Nectin are membrane glycoproteins belonging to the immunoglobulin family. PVRP-1 mediates Ca+2-independent cell adhesion[1]. PVRP-2 and PVRP-3 are components of the adherens junction[2]. PVRP-4 binds PVRP-1. Relevance PVRP-4 is involved in tumor cell migration. Structural highlights Poliovirus receptor-related protein 1 interactions with herpes virus envelope glycoprotein. (PDB code 4myw)

spinqualitylabelsall models Poliovirus receptor-related protein 1 (green) complex with herpes virus envelope glycoprotein (magenta) (PDB code 4myw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of poliovirus receptor-related protein

Updated on 08-August-2019

Poliovirus receptor-related protein 1

4myw, 3u82, 3sku – hPVRP1 + envelope glycoprotein D – human

5x5w – PVRP1 domain D1 + glycoprotein D - pig

4fmf, 3u83, 3alp – hPVRP1 domains D1-D3

5b21 – mPVRP1 domain D1 - mouse

2l7j – hPVRP1 domain D3 - NMR

Poliovirus receptor-related protein 2

4hza, 4dfh, 3r0n – hPVRP2 domain D1

4dfi – hPVRP2 domain D1 (mutant)

5v52 – hPVRP2 domain D1 + TIGIT

4fmk, 4fn0 – mPVRP2 domains D1-D2

4fs0 – mPVRP2 domains D1-D2 (mutant)

Poliovirus receptor-related protein 3

4fom – hPVRP3 domains D1-D3

5b22 – mPVRP3 domains D1-D2

Poliovirus receptor-related protein 4

4jjh – hPVRP4 domain D1

4gjt – hPVRP4 domain D1 + hemagglutinin glycoprotein

4frw – hPVRP4 domains D1-D2

References

1. ↑ Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science. 1998 Jun 5;280(5369):1618-20. PMID:9616127
2. ↑ Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P. The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. Blood. 1998 Dec 15;92(12):4602-11. PMID:9845526