Function
Poly (ADP-ribose) glycohydrolase (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers[1].
Relevance
PARG deficiency leads to cell death. Over-activation of PARP due to oxidative stress culminates in cell dysfunction and necrosis. PARP inhibitors have anti-inflammatory effect[2].
Structural highlights
The of PARG contains [3]. Water molecules are shown as red spheres.
3D Structures of poly (ADP-ribose) glycohydrolase
Poly(ADP-ribose) glycohydrolase 3D structures