Polyneuridine Aldehyde Esterase

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Polyneuridine aldehyde esterase complex with vellosimine 3gzj

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3D structures of polyneuridine aldehyde esterase

2wfm – SePAE (mutant) – Serpentwood
2wfl – SePAE
3gzj – SePAE + 16-epi-vellosimine


  1. Mattern-Dogru E, Ma X, Hartmann J, Decker H, Stockigt J. Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis. Eur J Biochem. 2002 Jun;269(12):2889-96. PMID:12071952
  2. Yang L, Hill M, Wang M, Panjikar S, Stockigt J. Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids. Angew Chem Int Ed Engl. 2009;48(28):5211-3. PMID:19496101 doi:10.1002/anie.200900150

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Alexander Berchansky, Michal Harel, Liuqing Yang, Joel L. Sussman

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