Protein G

From Proteopedia

Protein G or immunoglobulin-binding protein G (ProG) is a cell surface protein from Streptococcal bacteria which binds Fab and Fc regions of immunoglobulins[1]. For ProG immunoglobulin-binding domain see Chameleon peptide.

spinqualitylabelsall models Protein G domain II (grey) complex with mouse Fab heavy chain (red) and light chain (aqua) (PDB code 1uwx). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of protein G

Updated on 03-February-2022

Streptococcus Protein G residues 2-68

6u8c – StProG + antibody – Streptococcus

Streptococcus Protein G residues 56-118

1uwx – StProG + Igg1 Fab

1qkz – StProG (mutant) + Igg1 Fab + peptide antigen

Streptococcus Protein G residues 189-244

1em7 – StProG (mutant)

Streptococcus Protein G B1 domain residues 228-282

1pga, 1pgb, 2ju6, 2rmm, 2rpv, 1mpe, 1q10, 2j52, 2j53, 2k0p, 3mp9, 1gb1, 2gi9 - StProG

2gb1, 3gb1, 5ub0, 5ubs, 5uce,2n9k, 5ucf, 2n9l, 2plp, 6che, 1qmt, 2lgi, 2nmq, 2rpv - StProG - NMR

1mvk, 1fcl, 1fd6, 1em7, 3v3x, 6c9o, 6kmc, 6nla, 6nlb, 6nl9, 6nl8, 6nl7, 6nl6, 5ofs, 6cne, 6cpz, 4wh4, 6l9b, 6lji, 5bmi, 5bmh, 6l91, 6l9d, 5hg2, 5hfy, 5hi1 – StProG (mutant)

1q10, 2rmm, 2k0p, 2ju6 – StProG (mutant) – NMR

1mi0, 1mhx – ProG (mutant) – Finegoldia magna

Streptococcus Protein G albumin-binding domain residues 254-299

1gjs, 1gjt - StProG albumin-binding domain - NMR

Streptococcus Protein G 3rd Igg-binding domain residues 300-357

3fil, 1pgx, 2igd, 1igd - StProG

3v3x, 5bmg, 6c9o, 6cte, 6nl6, 6nl7, 6nl8, 6nl9, 6nlb – StProG (mutant)

2plp, 1p7f, 1p7e, 2n7j, 2lum - StProG - NMR

2jsv, 2kq4, 2kwd, 1fcl, 1fd6 - StProG (mutant) - NMR

1igc – StProG + Igg1 Fab

6o41 – StProG + antibody

Streptococcus Protein G domains II+III residues 367-430

2on8, 2igg - StProG

2igh – StProG – NMR

2onq, 2on8 – StProG (mutant)

1gb4, 6njf – StProG (mutant) – NMR

1fcc – StProG + Igg1 Fc

Streptococcus Protein G residues 443-497

1p7e, 1p7f, 2lum, 2oed - StProG - NMR

1zxh - StProG (mutant) - NMR

6oc7 – StProG + antibody

6wfw – StProG + antibody + peptide

Protein G

1gb1, 2gb1, 2igg, 2igh - SgProG immunoglobulin-binding domain – Streptomyces griseus – NMR

2igg, 2igh - SgProG immunoglobulin-binding domains II+III – NMR

2gi9, 2qmt – SaProG domain B1 (mutant) – Staphylococcus aureus

2klk - SaProG immunoglobulin-binding domain - NMR

References

1. ↑ Erntell M, Myhre EB, Sjobring U, Bjorck L. Streptococcal protein G has affinity for both Fab- and Fc-fragments of human IgG. Mol Immunol. 1988 Feb;25(2):121-6. PMID:3131664