Function
Pyranose oxidase or pyranose 2-oxidase (P2O) catalyzes the conversion of D-glucose and molecular oxygen to 2-dehydro-D-glucose and H2O2. It is abundant in lignin-degrading white rot fungi. P2O is a flavoprotein containing the . P2O oxidizes several aldopyranoses with the preferred electron donors being D-glucose, D-xylose and D-sorbose[1].
Relevance
Converting common sugars and sugar derivatives with P2O provides a pool of sugar-derived intermediates for the synthesis of rare sugars, fine chemicals and drugs.
Structural highlights
The is gated by a highly conserved loop which determines the substrate specificity. Water molecules are shown as red spheres. The active site contains the FAD cofactor[2].
