Function
Pyrroline-5-carboxylate dehydrogenase (PCD) catalyzes the reversible dehydrogenation of 1-pyrroline-5-carboxylate to glutamate using NAD or NADP as cofactors. PCD participates in glutamate, proline and arginine metabolism. PCD is the second enzyme in proline degradation hence it is important in stress conditions when plants accumulate proline[1]. See also Aldehyde dehydrogenase.
Disease
Mutation in PCD results in the metabolic disorder type II hyperprolinemia[2].
Structural highlights
PCD ligand . Water molecules are shown as red spheres. A [3].