RNA uridylyltransferase

From Proteopedia

spinqualitylabelsall models RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry 2q0f) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function RNA uridylyltransferase or terminal uridylyltransferase or TUTase (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation[1]. For additional details on TUT-4 see Terminal Uridylyl Transferase. Drosophila melanogaster TUTase is called TUTase Tailor. It is forming the uridylation-mediated processing complex which degrades a variety ofncRNAs in the cytoplasm [2],.[3] Structural highlights [4]. Water molecules are shown as red spheres. .

3D Structures of RNA uridylyltransferase

Updated on 11-August-2024

References

1. ↑ Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23;366(3):882-99. Epub 2006 Dec 2. PMID:17189640 doi:10.1016/j.jmb.2006.11.065
2. ↑ Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 , Jul 2. PMID:26145174 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.034
3. ↑ Reimão-Pinto MM, Manzenreither RA, Burkard TR, Sledz P, Jinek M, Mechtler K, Ameres SL. Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila. EMBO J. 2016 Nov 15;35(22):2417-2434. PMID:27729457 doi:10.15252/embj.201695164
4. ↑ Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418