Nucleoprotein

From Proteopedia

(Redirected from RNP)
Jump to: navigation, search


Contents

Function

Nucleoproteins (NP) are proteins associated with DNA or RNA[1]. NPs which contain RNA are called ribonucleoproteins (RNPs). The NP RNA-recognition motif is named RRM.
The small nuclear ribonucleoproteins (snRNPs) are RNA-protein complexes which form part of the spliceosome[2]. For details on SnRNP see Azoarcus group I intron.
The heterogenous nuclear ribonucleoproteins (hnRNP) are RNA-protein complexes which associates with the splicing apparatus and prevent the folding of pre-mRNA[3].
For details on heterogenous nuclear ribonucleoproteins see HnRNP A1.
For homology model and multiple sequence alignment see User:Michael Strong/H1N1/NP and User:Michael Strong/H1N1/NP/MSA.
For details on HIV-1 nucleoprotein see HIV-1 Nucleocapsid Protein (NC).

Structural highlights

  • TTP binding site in Nucleoprotein from Lassa virus (3mx2). Water molecules are shown as red spheres.
  • Zn coordination site.

3D Structures of Nucleoprotein

Nucleoprotein 3D structures


Nucleoprotein from Lassa virus trimer complex with TTP and Zn+2 ions (grey) 3mx2

Drag the structure with the mouse to rotate

References

  1. ↑ Echols H. Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination. J Biol Chem. 1990 Sep 5;265(25):14697-700. PMID:2203758
  2. ↑ Yong J, Wan L, Dreyfuss G. Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol. 2004 May;14(5):226-32. PMID:15130578 doi:http://dx.doi.org/10.1016/j.tcb.2004.03.010
  3. ↑ He Y, Smith R. Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. Cell Mol Life Sci. 2009 Apr;66(7):1239-56. doi: 10.1007/s00018-008-8532-1. PMID:19099192 doi:http://dx.doi.org/10.1007/s00018-008-8532-1

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

Retrieved from "http://proteopedia.org/wiki/index.php/Nucleoprotein"
Personal tools