Remicade (Infliximab)

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Remicade (Infliximab)

4g3y, Biological Assembly 1, Resolution 2.6Å

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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Liang S, Dai J, Hou S, Su L, Zhang D, Guo H, Hu S, Wang H, Rao Z, Guo Y, Lou Z. Structural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab. J Biol Chem. 2013 May 10;288(19):13799-807. doi: 10.1074/jbc.M112.433961. Epub, 2013 Mar 15. PMID:23504311 doi:10.1074/jbc.M112.433961
  2. de Ridder L, Benninga MA, Taminiau JA, Hommes DW, van Deventer SJ. Infliximab use in children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):3-14. PMID:17592358 doi:
  3. 3.0 3.1 Wong M, Ziring D, Korin Y, Desai S, Kim S, Lin J, Gjertson D, Braun J, Reed E, Singh RR. TNFalpha blockade in human diseases: mechanisms and future directions. Clin Immunol. 2008 Feb;126(2):121-36. Epub 2007 Oct 3. PMID:17916444 doi:
  4. Cseh K, Beutler B. Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein. J Biol Chem. 1989 Sep 25;264(27):16256-60. PMID:2777790
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Ramsey, L. (2015). One of the world’s blockbuster drugs might not exist if its research hadn't flopped in a major way. Retrieved from
  6. Steenholdt C, Coskun M, Buhl S, Bendtzen K, Ainsworth MA, Brynskov J, Nielsen OH. Circulating Cytokines and Cytokine Receptors in Infliximab Treatment Failure Due to TNF-alpha Independent Crohn Disease. Medicine (Baltimore). 2016 Apr;95(16):e3417. doi: 10.1097/MD.0000000000003417. PMID:27100432 doi:
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 REMICADE (Infliximab) for IV injection. (2002). ( No. 1242). Malvern, PA: Centocor, INC.
  8. 8.0 8.1 Grainger, R., & Harrison, A. A. (2007). Infliximab in the treatment of ankylosing spondylitis. Biologics, 1(2), 163-171.
  9. 9.0 9.1 9.2 9.3 Kircik LH, Del Rosso JQ. Anti-TNF agents for the treatment of psoriasis. J Drugs Dermatol. 2009 Jun;8(6):546-59. PMID:19537380
  10. National Psoriasis Foundation. (2016). Moderate to severe psoriasis and psoriatic arthritis: Biologic drugs. Retrieved from

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Alexander Berchansky, Zach Schuhmacher., Michal Harel

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