From Proteopedia

Jump to: navigation, search

Glycosylated human renin (PDB code 2ren)

Drag the structure with the mouse to rotate

3D structures of renin

Updated on 08-December-2019

1bbs, 2ren – hRen – human
1rne – hRen + transition state analog inhibitor
1hrn, 1bil, 1bim, 2bks, 2bkt, 2fs4, 2g1n, 2g1o, 2g1r, 2g1s, 2g1y, 2g21, 2g22, 2g24, 2g26, 2g27, 2g20, 2i4q, 2iko, 2iku, 2il2, 2v0z, 2v10, 2v11, 3d91, 2v13, 2v16, 3gw5, 3g6z, 3g70, 3g72, 3km4, 3k1w, 3oqf, 3oot, 3oqk, 3oad, 3oag, 3own, 3o9l, 3q3t, 3sfc, 3q4b, 3q5h, 3vsw, 3vsx, 2v12, 3vuc, 3vyd, 3vye, 3vyf, 4gj5, 4gj6, 4gj7, 4gj8, 4gj9, 4gja, 4gjb, 4gjc, 4gjd, 4pyv, 4q1n, 4ryc, 4ryg, 4rz1, 4s1g, 4xx3, 4xx4, 5kod, 5kos, 5kot, 5t4s, 5sxn, 5sy2, 5sy3, 5sz9, 5koq, 5tmg, 5tmk, 5v8v, 5vpm, 5vrp - hRen + inhibitor
2x0b – hRen + angiotensinogen
6i3f – hRen (mutant) + angiotensinogen
5mkt – mRen-1 – mouse
1smr - mRen + peptide inhibitor
5mlg – Ren – rat

3vcm, 4amt – hProrenin


  1. Margrane M. and the UnitProt consortium, Uniprot Knowledgebase: a hub of integrated protein data, Database, 2012: bar009 (2011). Public Accession Number P00797
  2. Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. Science. 1989 Mar 10;243(4896):1346-51. PMID:2493678
  3. Suguna K, Padlan EA, Smith CW, Carlson WD, Davies DR. Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7009-13. PMID:3313384
  4. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002 Jun;109(11):1417-27. PMID:12045255 doi:10.1172/JCI14276
  5. Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation. 2005 Mar 1;111(8):1012-8. Epub 2005 Feb 21. PMID:15723979 doi:10.1161/01.CIR.0000156466.02908.ED
  6. Webb RL, Schiering N, Sedrani R, Maibaum J. Direct renin inhibitors as a new therapy for hypertension. J Med Chem. 2010 Nov 11;53(21):7490-520. PMID:20731374 doi:10.1021/jm901885s
  7. Politi A, Durdagi S, Moutevelis-Minakakis P, Kokotos G, Mavromoustakos T. Development of accurate binding affinity predictions of novel renin inhibitors through molecular docking studies. J Mol Graph Model. 2010 Nov;29(3):425-35. Epub 2010 Aug 27. PMID:20855222 doi:10.1016/j.jmgm.2010.08.003
  8. Wu Y, Shi C, Sun X, Wu X, Sun H. Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin. Bioorg Med Chem. 2011 Jul 15;19(14):4238-49. Epub 2011 Jun 1. PMID:21708467 doi:10.1016/j.bmc.2011.05.059
  9. Lowes, Robert. "Aliskiren in Certain Rx Combos Nixed for Diabetic Patients." Webscape Medical News. Web MD, 2012. 20 April 2012. <>
  10. Rahuel J, Rasetti V, Maibaum J, Rueger H, Goschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grutter MG. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem Biol. 2000 Jul;7(7):493-504. PMID:10903938
  11. Keevil SF, Dolke G, Armstrong P, Smith MA. Calibration of a 0.08 Tesla magnetic resonance imager for in vivo T1 and T2 measurement. Br J Radiol. 1992 May;65(773):438-42. PMID:1611425
  12. Zivna M, Hulkova H, Matignon M, Hodanova K, Vylet'al P, Kalbacova M, Baresova V, Sikora J, Blazkova H, Zivny J, Ivanek R, Stranecky V, Sovova J, Claes K, Lerut E, Fryns JP, Hart PS, Hart TC, Adams JN, Pawtowski A, Clemessy M, Gasc JM, Gubler MC, Antignac C, Elleder M, Kapp K, Grimbert P, Bleyer AJ, Kmoch S. Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet. 2009 Aug;85(2):204-13. Epub 2009 Aug 6. PMID:19664745 doi:10.1016/j.ajhg.2009.07.010

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Matthew Tugwell

Personal tools