Replication protein E1

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Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code 1ksx)

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3D structures of replication protein E1

Updated on 13-February-2022

Domains: helicase 301-605; DNA-binding (DBD) 286-365

1r9w - HpvRPE1 DBD – Human papilloma virus 18
1tue - HpvRPE1 428-631 (mutant) + RPE2 TAD
2gxa - DpvRPE1 helicase domain + DNA + ADP – Delta papilloma virus 4
5a9k - BpvRPE1 helicase domain – Bovine papilloma virus - Cryo EM
2v9p - BpvRPE1 helicase domain
1f08 - BpvRPE1 DBD
1ksx, 1ksy - BpvRPE1 DBD + DNA
7apd - BpvRPE1 helicase domain + DNA – Cryo EM

References

  1. ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
  2. ↑ Baedyananda F, Chaiwongkot A, Bhattarakosol P. Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression. Intervirology. 2017;60(5):171-180. doi: 10.1159/000487048. Epub 2018 Mar 1. PMID:29495005 doi:http://dx.doi.org/10.1159/000487048
  3. ↑ Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. EMBO J. 2002 Mar 15;21(6):1487-96. PMID:11889054 doi:http://dx.doi.org/10.1093/emboj/21.6.1487

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