Ribosomal protein L19

From Proteopedia

spinqualitylabelsall models Ribosomal protein L19 (PDB code 4v5k) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Ribosomal protein L19 (RPL19) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits[1]. Relevance RPL19 is highly expressed in human breast tumors[2]. RPL19 is a prognostic marker for prostate cancer[3].

3D Structures of Ribosomal protein L19

Updated on 22-October-2017

L19 in part of 80S ribosome

2ww9, 2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM
2wwb - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM

References

1. ↑ Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, Yasuda M, Uramoto H, Hanagiri T, Yasumoto K. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. Cancer Sci. 2010 Jan;101(1):46-53. doi: 10.1111/j.1349-7006.2009.01351.x. Epub, 2009 Sep 9. PMID:19799608 doi:http://dx.doi.org/10.1111/j.1349-7006.2009.01351.x
2. ↑ Henry JL, Coggin DL, King CR. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res. 1993 Mar 15;53(6):1403-8. PMID:8095182
3. ↑ Bee A, Ke Y, Forootan S, Lin K, Beesley C, Forrest SE, Foster CS. Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2061-5. PMID:16609016 doi:http://dx.doi.org/10.1158/1078-0432.CCR-05-2445