Ribosomal protein L7/L12

From Proteopedia

spinqualitylabelsall models Ribosomal protein L7/L12 (PDB code 1dd3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Ribosomal protein L7 (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7[1]. In the archaea, the L7Ae acts as a subunit of RNase P. For more details see 15.5kD/Snu13/L7Ae. Relevance RPL7 is an auto antigen in patients suffering from systemic lupus erythematosus and other connective tissue diseases[2].

3D Structures of Ribosomal protein L7

Updated on 05-January-2020

References

1. ↑ Babiano R, Badis G, Saveanu C, Namane A, Doyen A, Diaz-Quintana A, Jacquier A, Fromont-Racine M, de la Cruz J. Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles. Nucleic Acids Res. 2013 Nov;41(20):9461-70. doi: 10.1093/nar/gkt726. Epub 2013, Aug 13. PMID:23945946 doi:http://dx.doi.org/10.1093/nar/gkt726
2. ↑ von Mikecz A, Hemmerich P, Peter HH, Krawinkel U. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. Immunobiology. 1994 Dec;192(1-2):137-54. PMID:7750987 doi:http://dx.doi.org/10.1016/S0171-2985(11)80413-4