SARS-CoV-2 enzyme 2'-O-MT

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Non-structural protein 16 (Nsp16): 2'-O-methyltransferase (2'-O-MT)

Nsp 16 is a methyltransferase enzyme that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. The N7-methyl guanosine cap is a prerequisite for binding of nsp16, therefore plays an essential role in viral mRNAs cap methylation which is essential to evade the host immune system.[1][2]

Crystal structure of the SARS-CoV-2 nsp16 (green)-nsp10 (red) complex (PDB: 6w4h).

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Michal Harel, Lea C. von Soosten, Cameron Fyfe, Jaime Prilusky

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