SUMO conjugating enzyme Ubc9

From Proteopedia

SUMO conjugating enzyme Ubc9 tetramer 2gjd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function SUMO conjugating enzyme Ubc9 accepts the ubiquitin-like SUMOs and catalyzes their attachment to other proteins with the help of E3 ligase[1]. Relevance Ubc9 inhibitors may be therapeutic agents against fibrotic diseases like rheumatoid arthritis[2][3].

3D Structures of SUMO conjugating enzyme Ubc9

Updated on 10-December-2023

References

1. ↑ Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A. Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013, May 2. PMID:23644018 doi:http://dx.doi.org/10.1016/j.molcel.2013.03.027
2. ↑ Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH. Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub, 2012 Aug 17. PMID:22904261 doi:http://dx.doi.org/10.1136/annrheumdis-2012-201746
3. ↑ Li F, Li X, Kou L, Li Y, Meng F, Ma F. SUMO-conjugating enzyme UBC9 promotes proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2014 Aug;37(4):1134-41. doi: 10.1007/s10753-014-9837-x. PMID:24531852 doi:http://dx.doi.org/10.1007/s10753-014-9837-x