Succinate-semialdehyde dehydrogenase

From Proteopedia

Function Succinate-semialdehyde dehydrogenase or α-ketoglutaric semialdehyde dehydrogenase or succinyl-CoA reductase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism[1]. See also Aldehyde dehydrogenase. Disease SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia[2]. Structural highlights The active site of SSD contains the substrate succinate semialdehyde and the cofactor NADP[3]. Water molecules are shown as red spheres. Whole binding site.

spinqualitylabelsall models Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of succinate-semialdehyde dehydrogenase

Updated on 06-December-2023

Succinate-semialdehyde dehydrogenase

2w8n, 2w8o – hSSD - human

2w8p – hSSD (mutant)

4it9, 3vz1 – SySSD - Synechococcus

3vz2 – SySSD (mutant)

4v6h – SSD – Burkholderia pseudomallei

5vbf – SSD – Burkholderia vietnamiensis

3rh9 – SSD – Marinobacter aquaeolei

4ogd – SpSSD – Streptococcus pyogenes

5x5t – AbSSD – Azuspirillum brasilense

Succinate-semialdehyde dehydrogenase complexes

2w8q – hSSD (mutant) + succinate

2w8r – hSSD (mutant) + ADP

4ita – SySSD + NADPH

4itb – SySSD + NADPH + succinic semialdehyde

3vz3 – SySSD (mutant) + NADPH + succinic semialdehyde

3jz4 – SSD + NADPH – Escherichia coli

4oht – SpSSD + NADPH

4ywu, 4ywv – SySSD + oxobutanoic acid + succinic semialdehyde

5x5u – AbSSD + NAD

8c54 – SSD + NADH – Rhizobium leguminosarum – Cryo EM

8cej – CkSSD + mesaconyl-c1-CoA – Clostridium kluyveri

8cek – CkSSD + NADPH

References

1. ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
2. ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
3. ↑ Yuan Z, Yin B, Wei D, Yuan YR. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase. J Struct Biol. 2013 May;182(2):125-35. doi: 10.1016/j.jsb.2013.03.001. Epub 2013 , Mar 13. PMID:23500184 doi:10.1016/j.jsb.2013.03.001