Function
Succinate-semialdehyde dehydrogenase or α-ketoglutaric semialdehyde dehydrogenase or succinyl-CoA reductase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism[1]. See also Aldehyde dehydrogenase.
Disease
SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia[2].
Structural highlights
The active site of SSD contains the and the [3]. Water molecules are shown as red spheres. .