Symporter

From Proteopedia

Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code 4d2c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of symporter Function Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction[1]. Disease Mutations in sodium/iodide symporter cause iodide transport defects[2]. Structural highlights Dipeptide: between its N- and C-terminal bundles[3]. 3D Structures of symporter Symporter 3D structures

References

1. ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
2. ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
3. ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403