Function
Syntenin (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes[1]
Relevance
Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer
Structural highlights
The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the [2]. The peptide forms a β strand which runs antiparallel to the PDZ β strand. . Water molecules are shown as red spheres.
Syntenin 3D structures
3D structures of syntenin
