Function
Syntrophins (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling [1].
Disease
Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death[2].
Structural highlights
Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. β-finger via its binding groove[3].
